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BioScience Talks

BioScience Talks , published by the American Institute of Biological Sciences, is the monthly discussion podcast of the journal BioScience. AIBS is a registered US 501c3 nonprofit organization, EIN: 53-0220853.
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Now displaying: January, 2019
Jan 9, 2019

Richard Pelikan

 Austin SchwinnNew tools are making it easier to understand not only our genetic code but also the ways that the code's three-dimensional structure contributes to gene expression. This understanding will be vital in the search for cures to diseases with multiple and complex causes, such as lupus. On this episode of BioScience Talks, we discuss one such tool. It's the product of a collaboration among data scientists, medical scientists, and software engineers, and the new "xapp" allows researchers to view the 3D, looped structure of chromatin and examine the ways in which those loops affect our genes' expression.

Richard Pelikan, a bioinformatician at the Oklahoma Medical Research Foundation, and Austin Schwinn, a data scientist at Exaptive, joined us on this episode to discuss the collaboration, epigenetics, chromatin looping, and the future of understanding human disease. Images discussed in the podcast can be found below the links.

2D image

3D representation. From association to mechanism in complex disease genetics: the role of the 3D genome. Fu et al., Arthritis Res Ther. (2018); 20: 216. https://doi.org/10.1186/s13075-018-1721-x

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