The benefits of specimen collection are well known. Natural-history archives are increasingly used by researchers to investigate evolutionary processes, examine the effects of climate and environmental change, explore the ecology of emerging diseases, and so on. However, the effects of specimen removal on the wild populations and communities is a question that has rarely been addressed. Writing in BioScience, Dr. Andrew Hope and his colleagues draw on historical data from a Long-Term Ecological Research site to examine the effects of one such specimen collection program. In this episode of the podcast, we discuss those results in particular, as well as broader the research opportunities afforded by natural-history collections.