Each year, tens of thousands of patients undergo invasive surgery to repair perforated eardrums. The surgery, called tympanoplasty, is time consuming, costly, and difficult for patients—many of whom are children. Seeing an opportunity to fill an important unmet medical need, the founders behind Virginia startup Tympanogen have developed a technology aimed at reducing the need for these challenging operations. The product, called Perf-Fix, is a light-cured hydrogel applied in a doctor's office to give the patient's own tissue a scaffold on which to heal and rebuild, circumventing the need for surgical intervention.
Co-Founder and CEO Dr. Elaine Horn-Ranney joins us on this episode of our Impact Series to discuss Perf-Fix, what it takes to run a start-up, and some of the many other potential applications for Tympanogen's technology.
Agricultural areas are often considered distinct from local ecosystems, and in many cases, such an assessment rings true. Single-crop farmlands, reliant on the liberal use of pest- and herbicides, often limit local biodiversity and species interactions. However, in other agricultural settings, robust ecosystems thrive, intermingled with crops and supporting a diversity of species.
One such acroecosystem is coffee's. On shade-coffee farms, the coffee plant is consumed by numerous pests, including the green coffee scale, coffee berry borer, and coffee rust disease. In turn, these species are regulated by a variety of natural enemies, through processes of often staggering complexity. In a major BioScience Overview article, John Vandermeer of the University of Michigan and his colleagues aim to untangle such complexities and get at the heart of pest control in the coffee system, emphasizing the intersection of ecology with "the burgeoning field of complex systems, including references to chaos, critical transitions, hysteresis, basin or boundary collision, and spatial self-organization."
Dr. Vandermeer joins us on this episode of BioScience Talks to discuss the coffee agroecosystem—and the many species and dynamics that underlie it.
Peer review lies at the heart of the grant selection process and, by extension, the scientific enterprise itself. To inform their decisions, funders rely on grant reviewers—most of whom volunteer their time—to evaluate numerous proposals. However, despite its massive importance to science and society, peer review itself remains inadequately studied and often poorly understood.
To shed light on this critical institution, American Institute of Biological Sciences chief scientist Stephen Gallo and his colleagues recently published the results of a major survey. It is joined by a grant review report from Publons, a company housed within Clarivate Analytics that helps researchers track their research and review outputs and works to encourage greater recognition of scientists' work.
In this episode of BioScience Talks, we are joined by Stephen Gallo and Matthew Hayes, director of Publons, who discuss the survey results and shed light on the future of peer review.